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Clinical Trials for Small Cell Lung Cancer
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There are 445 active trials for advanced/metastatic small cell lung cancer.
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445 trials meet filter criteria.
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TrialFetch AI summary: Eligible patients are adults with locally advanced or metastatic solid tumors harboring a KRAS G12D mutation, who have progressed on or are intolerant to standard therapies and meet organ function and performance status criteria. The investigational drug TSN1611, an oral small molecule inhibitor targeting both active and inactive forms of KRAS G12D, is administered as monotherapy.
ClinicalTrials.gov ID: NCT06385925
TrialFetch AI summary: This trial enrolls adults with unresectable or metastatic solid tumors (including NSCLC, high-grade serous ovarian carcinoma, and uterine serous carcinoma), ECOG 0-1, and at least one accessible lesion for biopsy. Patients receive BMS-986463, a novel investigational antineoplastic agent with an undisclosed mechanism of action, as monotherapy.
ClinicalTrials.gov ID: NCT06476808
TrialFetch AI summary: This trial enrolls adults with locally advanced or metastatic NSCLC harboring EGFR (and in some cohorts, HER2) exon 20 insertion mutations who have received prior therapy, treating them with STX-721, an investigational oral irreversible tyrosine kinase inhibitor that selectively targets mutant EGFR and HER2.
ClinicalTrials.gov ID: NCT06043817
TrialFetch AI summary: Adults with advanced solid tumors and good performance status are eligible for this study of BMS-986507, a bispecific EGFR/HER3-targeting antibody-drug conjugate with a topoisomerase I inhibitor payload, in combination with either osimertinib or pembrolizumab. Key exclusions include untreated symptomatic CNS metastases, mixed SCLC/NSCLC, and severe infection or cardiac disease.
ClinicalTrials.gov ID: NCT06618287
TrialFetch AI summary: Adult patients with advanced or metastatic solid tumors harboring a KRAS G12D mutation (including pancreatic, colorectal, or NSCLC), ECOG 0-1, and no prior KRAS G12D inhibitor exposure are eligible for treatment with INCB161734, a selective oral KRAS G12D inhibitor, given alone or in combination with standard therapies (e.g., gemcitabine/nab-paclitaxel, mFOLFIRINOX, cetuximab, or retifanlimab).
ClinicalTrials.gov ID: NCT06179160
TrialFetch AI summary: This trial enrolls adults with advanced or metastatic solid tumors (including IDH-wildtype glioblastoma) harboring MTAP loss who have progressed on standard therapy, and tests TNG456, a selective, brain-penetrant PRMT5 inhibitor, as monotherapy or in combination with abemaciclib (CDK4/6 inhibitor). Eligible patients must have measurable disease, good performance status, and adequate organ function.
ClinicalTrials.gov ID: NCT06810544
TrialFetch AI summary: This trial enrolls adults with advanced, unresectable or metastatic solid tumors harboring any KRAS mutation who have progressed on or declined standard therapies; patients receive ALTA3263, an oral KRAS isoform-selective inhibitor that targets both active and inactive KRAS states and is designed to inhibit over 90% of known KRAS mutations, including G12D, G12V, and G12C. Prior KRAS inhibitor therapy is generally excluded.
ClinicalTrials.gov ID: NCT06835569
TrialFetch AI summary: This trial is enrolling adults with advanced or metastatic solid tumors, especially those with MET alterations, including NSCLC with METex14 mutations, to receive VERT-002, a first-in-class monoclonal antibody degrader of c-MET administered intravenously every 2 weeks. Patients must have limited prior therapy options and no available curative treatments.
ClinicalTrials.gov ID: NCT06669117
TrialFetch AI summary: This trial enrolls adults with metastatic HR+/HER2- breast cancer and other advanced solid tumors likely dependent on CDK4 activity, who have progressed on or are intolerant to standard therapies, to receive the investigational CDK4 inhibitor BGB-43395 (a selective CDK4 inhibitor with minimal CDK6 inhibition) as monotherapy or combined with fulvestrant or letrozole. Prior CDK4/6 inhibitor exposure is permitted and sometimes required, but prior selective CDK4 inhibitors are excluded.
ClinicalTrials.gov ID: NCT06120283
TrialFetch AI summary: This trial enrolls adults with advanced or metastatic solid tumors harboring KRAS mutations (including NSCLC, CRC, and PDAC) who have progressed after standard therapies, testing the investigational oral panKRAS inhibitor PF-07934040 (blocks RAF binding to KRAS) as monotherapy and in combination with standard regimens. Eligible patients must have limited treatment options; certain arms allow first-line patients for combination therapies.
ClinicalTrials.gov ID: NCT06447662