Clinical Trials for Pancreas Cancer

A Phase 2 Open-label Basket Study to Evaluate the Efficacy and Safety of Orally Administered Reversible Tyrosine Kinase Inhibitor BAY 2927088 in Participants With Metastatic or Unresectable Solid Tumors With HER2-activating Mutations

Investigational drug late phase

The trial is testing an investigational drug and is at least phase 2, suggesting that the drug has shown promise in phase 1 studies and might have a high chance of working well compared to other investigational drugs.

Active drug

Investigational drug(s) in this trial have shown anticancer activity in clinical trials

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

TrialFetch AI summary: This trial enrolls adults with metastatic or unresectable solid tumors (excluding NSCLC) harboring activating HER2 mutations, who have progressed on standard therapy or have no satisfactory alternatives. Patients receive BAY2927088, an oral reversible tyrosine kinase inhibitor targeting mutant HER2 and EGFR.

ClinicalTrials.gov ID: NCT06760819

A Phase 2/3, Multicenter, Randomized Open-Label Study of Zanzalintinib vs Everolimus in Participants With Previously Treated, Unresectable, Locally Advanced or Metastatic Neuroendocrine Tumors

Investigational drug late phase

The trial is testing an investigational drug and is at least phase 2, suggesting that the drug has shown promise in phase 1 studies and might have a high chance of working well compared to other investigational drugs.

Active drug

Investigational drug(s) in this trial have shown anticancer activity in clinical trials

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

TrialFetch AI summary: Adults with well-differentiated (Grade 1–3) unresectable or metastatic pancreatic or extra-pancreatic NETs with recent RECIST-defined progression and no prior VEGFR TKI or mTOR inhibitor are randomized to zanzalintinib (XL092, an oral multi-kinase inhibitor of VEGFR2/MET/TAM) versus everolimus. Excludes NECs and select NET subtypes; primary endpoint is PFS by blinded central review.

ClinicalTrials.gov ID: NCT06943755

A Phase 2 Single Arm Trial of Stereotactic Body Radiation Therapy Followed by Dual Immune Checkpoint Inhibition for Patients With Metastatic Pancreatic Ductal Adenocarcinoma - The Miami "EMPIRE" Trial - Eradication of Metastatic Pancreatic Cancer With Immuno-Radiation

Investigational drug late phase

The trial is testing an investigational drug and is at least phase 2, suggesting that the drug has shown promise in phase 1 studies and might have a high chance of working well compared to other investigational drugs.

Active drug

Investigational drug(s) in this trial have shown anticancer activity in clinical trials

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

TrialFetch AI summary: Adults with metastatic, microsatellite-stable pancreatic ductal adenocarcinoma that has progressed on at least one prior systemic therapy receive SBRT to selected lesion(s) followed by dual checkpoint blockade with botensilimab (Fc‑enhanced anti–CTLA‑4) plus balstilimab (anti–PD‑1). Eligible patients require ECOG 0–1, measurable disease, adequate organ function, ≤25% liver tumor burden, and no active CNS metastases or significant autoimmune/immunosuppression.

ClinicalTrials.gov ID: NCT06843551

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Ersodetug in Patients With Inadequately Controlled Hypoglycemia Due to Tumor-Associated Hyperinsulinism (tHI)

Investigational drug late phase

The trial is testing an investigational drug and is at least phase 2, suggesting that the drug has shown promise in phase 1 studies and might have a high chance of working well compared to other investigational drugs.

Active drug

Investigational drug(s) in this trial have shown anticancer activity in clinical trials

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

TrialFetch AI summary: Adults with tumor-associated hyperinsulinism—either insulin-secreting tumors or IGF‑2–mediated NICT—with refractory hypoglycemia despite standard therapies; ambulatory ICT patients are randomized to ersodetug (RZ358) 9 mg/kg IV plus standard care vs placebo, while hospitalized ICT/NICT and ambulatory IGF‑secreting tumor patients receive open‑label ersodetug. Ersodetug is a fully human monoclonal antibody that negatively allosterically modulates the insulin receptor to attenuate excessive insulin/IGF‑2 signaling to reduce hypoglycemia.

ClinicalTrials.gov ID: NCT06881992

A Randomized, Phase 2/3 Study Comparing BMS-986504 in Combination With Nab-paclitaxel and Gemcitabine Versus Placebo in Combination With Nab-paclitaxel and Gemcitabine in Participants With Untreated Metastatic Pancreatic Ductal Adenocarcinoma Harboring Homozygous MTAP Deletion

Investigational drug late phase

The trial is testing an investigational drug and is at least phase 2, suggesting that the drug has shown promise in phase 1 studies and might have a high chance of working well compared to other investigational drugs.

Active drug

Investigational drug(s) in this trial have shown anticancer activity in clinical trials

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

TrialFetch AI summary: Adults with untreated metastatic pancreatic ductal adenocarcinoma harboring homozygous MTAP deletion or demonstrable MTAP loss are randomized to nab-paclitaxel/gemcitabine with or without BMS-986504, a selective MTA-cooperative PRMT5 inhibitor exploiting synthetic lethality in MTAP-deleted tumors. One induction cycle of nab-paclitaxel/gemcitabine before randomization is permitted if no progression or intolerable toxicity.

ClinicalTrials.gov ID: NCT07076121

A Phase 3 Randomized, Open-Label Study of Atebimetinib in Combination With the Modified Gemcitabine and Nab-Paclitaxel Regimen Versus the Standard Gemcitabine and Nab-Paclitaxel Regimen for the Treatment of Patients With Metastatic Pancreatic Ductal Pancreatic Adenocarcinoma Cancer (MAPKeeper 301)

Investigational drug late phase

The trial is testing an investigational drug and is at least phase 2, suggesting that the drug has shown promise in phase 1 studies and might have a high chance of working well compared to other investigational drugs.

Active drug

Investigational drug(s) in this trial have shown anticancer activity in clinical trials

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

TrialFetch AI summary: Randomized open-label trial for adults with previously untreated metastatic pancreatic ductal adenocarcinoma, ECOG 0–1, measurable disease, and adequate organ function. Patients receive atebimetinib, an investigational oral MEK1/2 inhibitor targeting MAPK signaling, plus modified gemcitabine/nab-paclitaxel versus standard gemcitabine/nab-paclitaxel.

ClinicalTrials.gov ID: NCT07562152

RASolute 303: A Phase 3 Global, Multicenter, Open-label, Randomized, 3-Arm Study of Daraxonrasib Monotherapy or Daraxonrasib Plus Gemcitabine and Nab-paclitaxel Versus Gemcitabine and Nab-paclitaxel as a First-Line Treatment for Patients With Metastatic Pancreatic Adenocarcinoma

Investigational drug late phase

The trial is testing an investigational drug and is at least phase 2, suggesting that the drug has shown promise in phase 1 studies and might have a high chance of working well compared to other investigational drugs.

Active drug

Investigational drug(s) in this trial have shown anticancer activity in clinical trials

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

TrialFetch AI summary: Enrolling treatment-naive adults with recently diagnosed metastatic pancreatic adenocarcinoma, ECOG 0–1, measurable disease, and documented RAS mutation status. Patients are randomized to oral daraxonrasib, an investigational RAS(ON) inhibitor targeting active GTP-bound RAS signaling, either alone or with gemcitabine/nab-paclitaxel versus gemcitabine/nab-paclitaxel alone.

ClinicalTrials.gov ID: NCT07491445

A Phase 2 Study of BT5528 in Patients With Metastatic Pancreatic Ductal Adenocarcinoma

Investigational drug late phase

The trial is testing an investigational drug and is at least phase 2, suggesting that the drug has shown promise in phase 1 studies and might have a high chance of working well compared to other investigational drugs.

Active drug

Investigational drug(s) in this trial have shown anticancer activity in clinical trials

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

TrialFetch AI summary: Adults with metastatic pancreatic ductal adenocarcinoma, ECOG 0–1, measurable disease, and radiographic progression after exactly one prior systemic therapy receive nuzefatide pevedotin (BT5528) monotherapy. BT5528 is an EphA2-targeting bicyclic peptide–drug conjugate linked to MMAE, given every 2 weeks, with primary assessment of RECIST objective response.

ClinicalTrials.gov ID: NCT07450859

A Phase II Study of Temozolomide and Survivin Long Peptide Vaccine (SurVaxM) in Patients With Progressing Metastatic Neuroendocrine Carcinomas (NECs)

Investigational drug late phase

The trial is testing an investigational drug and is at least phase 2, suggesting that the drug has shown promise in phase 1 studies and might have a high chance of working well compared to other investigational drugs.

Active drug

Investigational drug(s) in this trial have shown anticancer activity in clinical trials

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

TrialFetch AI summary: Adults with measurable, progressing metastatic high-grade neuroendocrine tumors (GI, pancreatic, or thoracic; Ki-67 >20%) or neuroendocrine carcinoma of any origin except small cell lung cancer, after at least one prior systemic therapy and with survivin-positive tumor tissue, receive open-label temozolomide plus SurVaxM. SurVaxM is an investigational survivin-targeted peptide vaccine given with Montanide and sargramostim to induce anti-survivin immune responses.

ClinicalTrials.gov ID: NCT06202066

Phase 1 / 2 Multicenter Study of the Safety, Pharmacokinetics, and Preliminary Efficacy of APL-101 in Subjects With Non-Small Cell Lung Cancer With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors

Investigational drug late phase

The trial is testing an investigational drug and is at least phase 2, suggesting that the drug has shown promise in phase 1 studies and might have a high chance of working well compared to other investigational drugs.

Active drug

Investigational drug(s) in this trial have shown anticancer activity in clinical trials

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

Started >3 years ago

The trial was activated more than 3 years ago. This is not always bad but can indicate that the trial has less current treatments, or has had trouble getting enough patients to enroll due to other issues.

TrialFetch AI summary: The trial investigates APL-101, a selective c-MET receptor tyrosine kinase inhibitor, in adult patients with NSCLC exhibiting c-Met exon 14 skipping mutations, various solid tumors with MET alterations, and primary CNS tumors. It includes APL-101 monotherapy and combination therapy with EGFR inhibitors in cases of acquired MET amplification resistance.

ClinicalTrials.gov ID: NCT03175224