All Trials

A Phase II Randomized, Decentralized, De-escalation Study in Patients With Metastatic Hormone-Sensitive Prostate Cancer Achieving Optimal PSA Response (OPTIMAS)

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

TrialFetch AI summary: Adults with metastatic hormone-sensitive prostate adenocarcinoma who achieve a deep PSA response (≤0.2 ng/mL) receive relugolix (oral GnRH receptor antagonist) plus an ARPI (abiraterone, enzalutamide, apalutamide, or darolutamide), with randomization to intermittent versus continuous therapy in newly treated patients and a single-arm intermittent strategy for those already suppressed. Aims to reduce fatigue and preserve disease control while characterizing outcomes and quality of life with intermittent ADT/ARPI.

ClinicalTrials.gov ID: NCT07216248

A Dose Finding Study of MiniBeam RadioTherapy for Skin and Superficial Soft Tissue Tumors (MBRT1)

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

TrialFetch AI summary: Adults with primary, recurrent, or metastatic skin or superficial soft tissue tumors suitable for palliative orthovoltage RT receive MiniBeam Radiation Therapy delivered via a tungsten slit collimator in 2–3 fractions, which spatially fractionates dose into high “peaks” and low “valleys” to spare normal tissue. Excludes lesions likely to fully respond to standard palliative RT, prior overlapping RT, recent/planned BRAF/VEGF-targeted therapy or cytotoxic chemo during the DLT window, and lesions with unavoidable spinal cord exposure.

ClinicalTrials.gov ID: NCT07062003

Phase II Study of ELacestrant in Combination With Abemaciclib or Elacestrant Alone In p53 Wild Type, Estrogen Receptor-positive Advanced or recurrenT Endometrial Cancer (ELITE)

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

TrialFetch AI summary: Adults with advanced or recurrent ER-positive, p53 wild-type endometrial cancer after prior platinum and PD-1 inhibitor therapy (no dMMR/POLE, limited prior lines) are randomized to elacestrant, an oral SERD, alone or combined with abemaciclib, a CDK4/6 inhibitor. Suitable for ECOG 0–1 patients without prior CDK4/6/SERD exposure; stable treated CNS metastases allowed.

ClinicalTrials.gov ID: NCT07209449

Patient Preference for Subcutaneous vs. Intravenous Immune Therapy (PSI-Immune)

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

TrialFetch AI summary: Adults with locally advanced or metastatic solid tumors eligible for on-label PD-1 therapy (nivolumab or pembrolizumab) are randomized in a crossover design to receive standard PD-1 inhibitors via subcutaneous versus intravenous administration, assessing patient/clinician preference, satisfaction, QoL, safety, and selected clinical outcomes. Includes PD-(L)1–naïve patients or those willing to switch; excludes prior severe hypersensitivity and transplant history.

ClinicalTrials.gov ID: NCT07223424

A Phase 1b/2 Study of AVUTOMETINIB and Cetuximab in Participants With Advanced KRAS Mutated Colorectal Cancer

Active drug

Investigational drug(s) in this trial have shown anticancer activity in clinical trials

High burden on patient

The trial has a high burden on patients. An example would be a phase 1 trial with extra tumor biopsies and frequent pharmacokinetic blood draws.

Started >3 years ago

The trial was activated more than 3 years ago. This is not always bad but can indicate that the trial has less current treatments, or has had trouble getting enough patients to enroll due to other issues.

TrialFetch AI summary: Adults with metastatic KRAS-mutant colorectal adenocarcinoma after failure/intolerance of standard 5-FU/capecitabine, oxaliplatin, irinotecan, and anti-VEGF therapy (and prior IO for MSI-H) receive avutometinib (a dual RAF/MEK inhibitor that stabilizes inactive RAF–MEK complexes) plus cetuximab. Excludes prior MEK/EGFR/KRAS/SOS1/SHP2 inhibitors and those with significant cardiovascular/ocular risks or unstable CNS metastases.

ClinicalTrials.gov ID: NCT05200442

LUNG-05: Investigating Chemotherapy Effectiveness for NSCLC Metastatic Patients

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

TrialFetch AI summary: Adults with previously treated stage IV NSCLC (ECOG 0–2) eligible for standard cytotoxic chemotherapy receive NCCN-concordant agents (e.g., docetaxel, paclitaxel, gemcitabine, pemetrexed, vinorelbine) selected by the investigational OncoChoice ex vivo drug-responsiveness assay performed on fresh tumor/fluid samples. Single-arm study assessing objective response, with secondary endpoints including 6-month PFS, OS, and QoL.

ClinicalTrials.gov ID: NCT06576635

The Clinical Relevance of Margins in Frameless Stereotactic Radiosurgery for Intact Brain Metastases: a Randomized Trial of 0 vs 2 mm Margins

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

TrialFetch AI summary: Adults (ECOG 0–2) with histologically confirmed non-hematologic malignancy and 1–5 intact, well-circumscribed intraparenchymal brain metastases on MRI (each ≤3.0 cm; excluding brainstem/near optic apparatus, leptomeningeal disease, or recent cranial RT/SRS) are randomized to frameless LINAC-based stereotactic radiosurgery planned with either a 0 mm versus 2 mm GTV-to-PTV margin. The study tests whether omitting the PTV margin maintains intracranial control while reducing radiation-related imaging changes/toxicity (e.g., radionecrosis/pseudoprogression).

ClinicalTrials.gov ID: NCT02747303

Personalized Radiotherapy for Individualized Treatment Strategies and Monitoring (PRISM): A Multi-cohort Platform Trial of Adaptive Radiotherapy Approaches in Multiple Cancer Types

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

TrialFetch AI summary: Enrolling adults (ECOG 0–2) with newly diagnosed extensive-stage small cell lung cancer on standard platinum/etoposide plus PD-L1 inhibitor chemoimmunotherapy (≤3 cycles at enrollment, no prior thoracic RT) to receive response-adaptive ultrahypofractionated thoracic stereotactic RT (PULSAR) in up to three 7–10 Gy “pulses” timed around infusion days, with pulses omitted if complete response occurs. Also enrolling adults with 1–5 MRI-defined brain metastases (2–5 cm; brainstem 1.5–5 cm; no prior WBRT or prior focal therapy to target lesions) for two-pulse fractionated SRS/FSRT where a 4-week response MRI can de-escalate treatment by omitting pulse 2 if ≥25% volume reduction.

ClinicalTrials.gov ID: NCT07139990

A Phase 3, Randomized, Open-Label, Multicenter Study of Amivantamab in Addition to Carboplatin and Pembrolizumab, Compared to Standard of Care Platinum and Pembrolizumab and 5-FU, in Participants With Treatment-Naïve Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

TrialFetch AI summary: Enrolling adults with treatment-naïve, recurrent/metastatic incurable HNSCC of the oral cavity/oropharynx (HPV/p16-negative required)/hypopharynx/larynx (ECOG 0–1, measurable disease; excludes nasopharynx/unknown primary), this study randomizes patients to pembrolizumab + carboplatin with or without amivantamab. Amivantamab is a bispecific EGFR–MET antibody with Fc-mediated immune effector activity, and the control regimen is standard pembrolizumab + platinum (carboplatin/cisplatin) + 5-FU.

ClinicalTrials.gov ID: NCT07276399

A Randomized Phase 2 Trial of Fruquintinib and TAS-102 as Compared to Fruquintinib in Patients With Refractory Advanced/Metastatic Colorectal Cancer

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

TrialFetch AI summary: Enrolling adults with ECOG 0–1, measurable, mismatch repair–proficient/microsatellite-stable advanced/metastatic colorectal adenocarcinoma that has progressed on or is intolerant to standard metastatic CRC therapies (fluoropyrimidine, oxaliplatin, irinotecan, bevacizumab, and anti-EGFR for RAS wild-type), excluding MSI-H/dMMR, BRAF V600, and prior regorafenib/TAS-102/fruquintinib. Patients are randomized to fruquintinib (oral selective VEGFR-1/2/3 TKI anti-angiogenic) plus TAS-102 (trifluridine/tipiracil DNA-directed cytotoxic) versus fruquintinib alone.

ClinicalTrials.gov ID: NCT06992258