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There are 1731 active trials in our database.
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TrialFetch AI summary: Adults with CLDN18.2-positive, unresectable locally advanced or metastatic gastric/GEJ or pancreatic adenocarcinoma, ECOG 0–1. Tests the CLDN18.2×CD3 bispecific T‑cell engager ASP2138 as monotherapy and combined with pembrolizumab+mFOLFOX6 (first-line HER2‑negative gastric/GEJ), ramucirumab+paclitaxel (second-line gastric/GEJ), or mFOLFIRINOX (first-line pancreatic).
ClinicalTrials.gov ID: NCT05365581
TrialFetch AI summary: For patients ≥12 years with unresectable/metastatic fibrolamellar hepatocellular carcinoma or adults with other solid tumors harboring the DNAJB1‑PRKACA fusion, including checkpoint‑naïve and some checkpoint‑experienced FLC cohorts. Treatment combines an off‑the‑shelf DNAJB1‑PRKACA junction neoepitope peptide vaccine (adjuvanted with TLR1/2 agonist XS15) with nivolumab (PD‑1 inhibitor) and ipilimumab (CTLA‑4 inhibitor) to augment vaccine‑primed T‑cell responses; a re‑enrollment option may use nivolumab plus vaccine if prior CTLA‑4 toxicity.
ClinicalTrials.gov ID: NCT04248569
TrialFetch AI summary: Pediatric and young adult patients (1–21 years) with relapsed/refractory, AFP-high (≥100 ng/mL), HLA-A2–positive hepatoblastoma, HCN-NOS, or HCC receive a single infusion of autologous ET140203 T cells after lymphodepletion. ET140203 (JWATM-203) is an engineered T-cell therapy using an ARTEMIS receptor with a TCR-mimic that targets AFP158–166/HLA-A*02:01 to selectively kill AFP+/HLA-A2+ liver cancer cells.
ClinicalTrials.gov ID: NCT04634357
TrialFetch AI summary: Adults with advanced primary liver cancers (HCC or cholangiocarcinoma) or solid tumors with liver‑predominant metastases (≤2 extrahepatic sites), ECOG 0–1, receive oral AU409 in 28‑day cycles. AU409 is a first‑in‑class small‑molecule RNA transcription modulator designed to alter liver cancer transcription programs; key exclusions include untreated/symptomatic CNS metastases, significant cardiac risk, Child‑Pugh ≥B7 (for HCC), and strong CYP inducer/inhibitor use.
ClinicalTrials.gov ID: NCT05791448
TrialFetch AI summary: Adults with advanced or recurrent solid tumors lacking standard options receive BP1001-A, a neutral-charge liposomal antisense oligonucleotide targeting GRB2 to inhibit RAS/MAPK and PI3K/AKT signaling; the expansion cohort enrolls recurrent/persistent epithelial ovarian, primary peritoneal, fallopian tube, or endometrial cancers for BP1001-A combined with standard-dose paclitaxel. Key exclusions include CNS disease, significant recent cardiovascular events, inability to receive paclitaxel, and strong CYP3A4/2C8 modulators.
ClinicalTrials.gov ID: NCT04196257
TrialFetch AI summary: Adults with measurable, biopsy-accessible stage III (macroscopic nodal) or stage IV melanoma, ECOG 0–1, and no prior PD‑1/PD‑L1 or CTLA‑4 therapy receive ipilimumab plus nivolumab combined with CBL0137, a non-genotoxic DNA intercalator that traps FACT to activate p53 and suppress NF‑κB/HSF1/MYC. Excludes active autoimmune disease or need for immunosuppression; serial biopsies and blood draws required.
ClinicalTrials.gov ID: NCT05498792
TrialFetch AI summary: Eligible patients are adult women with relapsed/refractory locally advanced or metastatic breast cancer (ECOG 0–1) who have progressed after standard therapies or lack standard options; a dose-expansion cohort is restricted to measurable triple-negative disease (ER/PR <10%, HER2-negative) previously treated with at least one active TNBC regimen and with a biopsiable lesion. All participants receive oral OTS167PO, an investigational small-molecule inhibitor of maternal embryonic leucine zipper kinase (MELK), in single-arm dose escalation to define MTD with PK/safety characterization and TNBC expansion at the selected dose.
ClinicalTrials.gov ID: NCT02926690
TrialFetch AI summary: Enrolls adults with relapsed/refractory or treatment-ineligible advanced/metastatic solid tumors (ECOG 0–1) who have at least two injectable lesions, with emphasis on cutaneous and head/neck cancers (e.g., cSCC, BCC, melanoma, Merkel cell carcinoma, HNSCC) including anti–PD-1–refractory cohorts. Patients receive intratumoral MQ710/MQ719, a non-replicating modified vaccinia Ankara virotherapy (E5R-deleted to enhance cGAS/STING signaling and engineered to express Flt3L and OX40L), given in escalating multi-dose schedules alone or combined with systemic pembrolizumab (PD-1 inhibitor).
ClinicalTrials.gov ID: NCT05859074
TrialFetch AI summary: Enrolling adults (ECOG 0–1) with metastatic/unresectable solid tumors refractory to standard therapy (excluding melanoma, primary brain tumors/GBM, sarcoma, and pancreatic ductal adenocarcinoma; no active untreated brain mets), with expansion cohorts limited to ≤3 prior systemic lines and focused on PD-(L)1–naïve MSS colorectal cancer without liver metastases and PD-1 relapsed/refractory MSS endometrial cancer, RCC, or NSCLC. Patients receive IV ADU-1805 (anti-SIRPα mAb blocking the SIRPα–CD47 “don’t eat me” checkpoint to enhance myeloid/macrophage activity) every 3 weeks alone or with fixed-dose pembrolizumab every 3 weeks.
ClinicalTrials.gov ID: NCT05856981
TrialFetch AI summary: Adults with ECOG 0–2 melanoma (stage IIB–IV with progression on or within 6 months after adjuvant anti–PD-1, including select rare subtypes with metastatic immunotherapy failure) or unresectable stage II/III–IV soft tissue sarcoma with accessible measurable disease and early resistance/need to continue anti–PD-1 therapy are enrolled, requiring surgically obtainable tumor for vaccine manufacture. Patients receive an individualized autologous total tumor mRNA vaccine formulated in DOTAP lipid particles (IV 3-dose series) intended to enhance antigen presentation/innate activation and re-sensitize to checkpoint blockade, followed by continuation/resumption of anti–PD-1 per protocol.
ClinicalTrials.gov ID: NCT05264974