All Trials

A Multicenter, Randomized, Double-Blind, Active Comparator-Controlled, Adaptive Phase 2/3 Study to Evaluate the Safety and Efficacy of EIK1001 and Pembrolizumab Versus Placebo and Pembrolizumab as First-Line Therapy in Participants With Advanced Melanoma (TeLuRide-006)

Investigational drug late phase

The trial is testing an investigational drug and is at least phase 2, suggesting that the drug has shown promise in phase 1 studies and might have a high chance of working well compared to other investigational drugs.

Active drug

Investigational drug(s) in this trial have shown anticancer activity in clinical trials

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

TrialFetch AI summary: Adults with unresectable stage III/IV melanoma eligible for first-line pembrolizumab (ECOG 0–1; non-ocular; no prior systemic therapy for advanced disease) are randomized to pembrolizumab plus EIK1001 vs pembrolizumab plus placebo. EIK1001 is an IV dual TLR7/8 agonist that activates dendritic cells to enhance innate and adaptive antitumor immunity, aiming to improve PFS/OS over pembrolizumab alone.

ClinicalTrials.gov ID: NCT06697301

A Phase 2, Randomized, Double-Blind, Placebo- and Active-Comparator-Controlled Clinical Study of V940 (mRNA-4157) Plus Pembrolizumab Versus Placebo Plus Pembrolizumab in Participants With First-Line Advanced Melanoma (INTerpath-012)

Investigational drug late phase

The trial is testing an investigational drug and is at least phase 2, suggesting that the drug has shown promise in phase 1 studies and might have a high chance of working well compared to other investigational drugs.

Active drug

Investigational drug(s) in this trial have shown anticancer activity in clinical trials

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

TrialFetch AI summary: Adults with previously untreated, unresectable stage III/IV cutaneous melanoma (BRAF-mutant or wild-type) are randomized to pembrolizumab plus V940, an individualized lipid‑nanoparticle mRNA vaccine encoding up to 34 patient-specific neoantigens to prime CD4+/CD8+ T cells, versus pembrolizumab plus placebo. Requires measurable disease and tissue for sequencing; excludes ocular/mucosal melanoma but allows controlled HIV/HBV/HCV.

ClinicalTrials.gov ID: NCT06961006

A Phase 3 Study of Fixed Dose Combinations of Fianlimab and Cemiplimab Versus Relatlimab and Nivolumab in Participants With Unresectable or Metastatic Melanoma

Investigational drug late phase

The trial is testing an investigational drug and is at least phase 2, suggesting that the drug has shown promise in phase 1 studies and might have a high chance of working well compared to other investigational drugs.

Active drug

Investigational drug(s) in this trial have shown anticancer activity in clinical trials

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

TrialFetch AI summary: Adults with untreated unresectable stage III or metastatic cutaneous melanoma (ECOG 0–1, measurable disease; excludes uveal/acral/mucosal melanoma, active brain mets, and significant autoimmune disease) are randomized to fixed-dose fianlimab (anti–LAG-3) plus cemiplimab (anti–PD-1) versus the approved relatlimab (anti–LAG-3) plus nivolumab (anti–PD-1) first-line. Primary endpoint is BICR-assessed ORR, with key secondary PFS/OS and safety.

ClinicalTrials.gov ID: NCT06246916

Phase 2 Study of Ivonescimab in Patients With Cutaneous Squamous Cell Carcinoma

Investigational drug late phase

The trial is testing an investigational drug and is at least phase 2, suggesting that the drug has shown promise in phase 1 studies and might have a high chance of working well compared to other investigational drugs.

Active drug

Investigational drug(s) in this trial have shown anticancer activity in clinical trials

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

TrialFetch AI summary: Single-arm study for adults with unresectable or metastatic cSCC that has progressed on prior anti–PD-1 therapy (ECOG 0–1), treating with ivonescimab IV every 21 days. Ivonescimab is a bispecific tetravalent antibody targeting PD-1 and VEGF to enhance antitumor immunity and inhibit angiogenesis; key exclusions include significant prior immune toxicity, active autoimmune disease, and uncontrolled cardiovascular or thromboembolic risk.

ClinicalTrials.gov ID: NCT06567314

A Randomized, Open-Label, Phase 2/3 Study of Datopotamab Deruxtecan (Dato-DXd) Plus Carboplatin or Cisplatin Versus Gemcitabine Plus Carboplatin or Cisplatin in Participants With Locally Advanced or Metastatic Urothelial Carcinoma (la/mUC) Who Progressed During or After Enfortumab Vedotin (EV) Plus Pembrolizumab Combination Treatment TROPION-Urothelial03 (TU03)

Investigational drug late phase

The trial is testing an investigational drug and is at least phase 2, suggesting that the drug has shown promise in phase 1 studies and might have a high chance of working well compared to other investigational drugs.

Active drug

Investigational drug(s) in this trial have shown anticancer activity in clinical trials

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

TrialFetch AI summary: Adults with unresectable locally advanced or metastatic urothelial carcinoma who progressed during or after first-line enfortumab vedotin plus pembrolizumab are randomized to datopotamab deruxtecan (TROP2-directed antibody–drug conjugate with a topoisomerase I inhibitor payload) plus cisplatin/carboplatin versus gemcitabine plus platinum. Includes cisplatin-eligible and -ineligible patients (carboplatin used when cisplatin-ineligible); excludes prior TROP2 ADCs and non-urothelial variants like small cell, adenocarcinoma, and urachal.

ClinicalTrials.gov ID: NCT07129993

A Phase 3, Randomized, Open-label, Multicenter Clinical Study to Evaluate the Safety and Efficacy of MK-1084, Cetuximab, and mFOLFOX6 Versus mFOLFOX6 With or Without Bevacizumab as First-line Treatment of Participants With KRAS G12C-mutant, Locally Advanced Unresectable or Metastatic Colorectal Cancer (KANDLELIT-012)

Investigational drug late phase

The trial is testing an investigational drug and is at least phase 2, suggesting that the drug has shown promise in phase 1 studies and might have a high chance of working well compared to other investigational drugs.

Active drug

Investigational drug(s) in this trial have shown anticancer activity in clinical trials

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

TrialFetch AI summary: Adults with unresectable locally advanced or metastatic colorectal adenocarcinoma harboring a KRAS G12C mutation, treatment-naive in the first-line metastatic setting, are randomized to mFOLFOX6 ± bevacizumab versus mFOLFOX6 plus cetuximab and MK-1084, a selective covalent KRAS G12C inhibitor that locks KRAS in its inactive GDP-bound state. Key exclusions include active CNS metastases, DPD deficiency, significant uncontrolled cardiovascular disease, and conditions precluding bevacizumab; controlled HIV/HBV and cured/controlled HCV are allowed.

ClinicalTrials.gov ID: NCT06997497

A Randomized, Double-Blind, Active-Control, Multicenter Phase 3 Trial of Casdatifan and Cabozantinib Versus Placebo and Cabozantinib in Patients With Advanced Clear Cell Renal Cell Carcinoma

Investigational drug late phase

The trial is testing an investigational drug and is at least phase 2, suggesting that the drug has shown promise in phase 1 studies and might have a high chance of working well compared to other investigational drugs.

Active drug

Investigational drug(s) in this trial have shown anticancer activity in clinical trials

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

TrialFetch AI summary: Adults with unresectable or metastatic clear cell RCC who progressed on prior PD‑1/PD‑L1 therapy are randomized to casdatifan (AB521, a selective allosteric HIF‑2α inhibitor) plus cabozantinib versus cabozantinib plus placebo. Excludes prior HIF‑2α inhibitor or cabozantinib exposure; key goal is to improve PFS with the HIF‑2α/VEGFR–TKI combination.

ClinicalTrials.gov ID: NCT07011719

A Multicenter, Open-Label, Randomized, Controlled Study to Assess the Antitumor Activity of LNS8801 With and Without Pembrolizumab in Patients With Treatment-Refractory, Unresectable Melanoma

Investigational drug late phase

The trial is testing an investigational drug and is at least phase 2, suggesting that the drug has shown promise in phase 1 studies and might have a high chance of working well compared to other investigational drugs.

Active drug

Investigational drug(s) in this trial have shown anticancer activity in clinical trials

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

TrialFetch AI summary: Adults with unresectable/metastatic cutaneous melanoma that has progressed on prior anti–PD-1 therapy, ECOG 0–1, and homozygous consensus GPER genotype (C/C) are randomized to LNS8801 (oral GPER agonist) plus pembrolizumab, LNS8801 alone, or physician’s choice therapy (dacarbazine/temozolomide or standard immunotherapy options). Aims to test whether GPER activation, which may promote melanocytic differentiation and enhance PD‑1 responsiveness, improves PFS versus standard options.

ClinicalTrials.gov ID: NCT06624644

A Ph2, Randomized, Blinded, Placebo-Controlled Trial Investigating the Efficacy and Safety of Visugromab Versus Placebo, in Combination With Pembrolizumab, Pemetrexed, and Carboplatin, in 1L Treatment of Participants With Metastatic NSCLC (GDFATHER-NSCLC-01)

Investigational drug late phase

The trial is testing an investigational drug and is at least phase 2, suggesting that the drug has shown promise in phase 1 studies and might have a high chance of working well compared to other investigational drugs.

Active drug

Investigational drug(s) in this trial have shown anticancer activity in clinical trials

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

TrialFetch AI summary: Adults with newly diagnosed metastatic non-squamous NSCLC (ECOG 0–1) lacking actionable driver mutations receive pembrolizumab+pemetrexed+carboplatin with either visugromab or placebo; PD-L1 ≥50% allowed only when CPI monotherapy isn’t appropriate. Visugromab is a humanized anti–GDF-15 monoclonal antibody intended to enhance T-cell trafficking and overcome PD-(L)1 resistance.

ClinicalTrials.gov ID: NCT07098988

A Phase II, Open Label, Multicenter, Single Arm Study of WSD0922-FU for Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer With First-Line Osimertinib Treatment and Harbor a C797S Mutation

Investigational drug late phase

The trial is testing an investigational drug and is at least phase 2, suggesting that the drug has shown promise in phase 1 studies and might have a high chance of working well compared to other investigational drugs.

Active drug

Investigational drug(s) in this trial have shown anticancer activity in clinical trials

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

TrialFetch AI summary: Adults with locally advanced/metastatic EGFR-mutant NSCLC who progressed on first-line osimertinib via acquired EGFR C797S (including patients with stable brain mets) receive oral WSD0922-FU BID. WSD0922-FU is a brain-penetrant, reversible, non-ATP-competitive EGFR inhibitor designed to target sensitizing EGFR mutations and EGFRm/C797S with relative selectivity over wild-type EGFR.

ClinicalTrials.gov ID: NCT06868485