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Clinical Trials for Non-Small Cell Lung Cancer
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There are 367 active trials for advanced/metastatic non-small cell lung cancer.
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367 trials meet filter criteria.
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TrialFetch AI summary: Adults with unresectable, advanced, or metastatic solid tumors (including NSCLC, colorectal, HNSCC, pancreatic, ovarian, or breast cancer) that are both HLA-A*02:01 positive and harbor the TP53 R175H mutation, and who have progressed on prior therapy, may receive NT-175, an autologous T cell product genetically engineered with a TCR targeting TP53 R175H and rendered resistant to TGF-β mediated immunosuppression. Treatment includes leukapheresis, lymphodepletion (fludarabine/cyclophosphamide), NT-175 infusion, and short-course subcutaneous IL-2.
ClinicalTrials.gov ID: NCT05877599
TrialFetch AI summary: This trial enrolls adults with advanced or metastatic solid tumors—including NSCLC, MSS colorectal cancer, pancreatic, gastric/GEJ adenocarcinoma, or head and neck squamous cell carcinoma—with good performance status, to receive BMS-986484 (an investigational anti-FAP biologic) as monotherapy or combined with nivolumab. Eligible patients must have measurable disease by RECIST v1.1 and ECOG 0-1.
ClinicalTrials.gov ID: NCT06544655
TrialFetch AI summary: Adults with advanced solid tumors—such as high grade serous ovarian, squamous NSCLC, triple negative breast, gastric, colorectal, esophageal, bladder, head and neck, and select gynecologic cancers—who have progressed on standard therapies receive oral VLS-1488, a selective inhibitor of the mitotic kinesin KIF18A, given in 28-day cycles. Patients with active CNS metastases, prior KIF18A inhibitor exposure, or MSI-H/dMMR tumors are excluded.
ClinicalTrials.gov ID: NCT05902988
TrialFetch AI summary: This trial enrolls adults with platinum-refractory extensive stage small cell or stage IV non-small cell lung cancer previously treated with PD-1/PD-L1 inhibitors, evaluating autologous T cells engineered to express a GD2-directed CAR, IL-15 for enhanced persistence, and an inducible caspase 9 safety switch. Patients receive leukapheresis, ex vivo T cell modification, and a single infusion of this investigational CAR T cell therapy.
ClinicalTrials.gov ID: NCT05620342
TrialFetch AI summary: Eligible patients are adults with advanced solid tumors harboring a KRAS G12D mutation, measurable disease, ECOG 0-1, and prior systemic chemotherapy. The trial evaluates oral LY3962673, a selective KRAS G12D inhibitor, as monotherapy and in combination with standard chemotherapies (including agents such as FOLFOX, FOLFIRI, and gemcitabine/nab-paclitaxel).
ClinicalTrials.gov ID: NCT06586515
TrialFetch AI summary: This trial enrolls adults with locally advanced or metastatic solid tumors harboring HER2 aberrations (mutations, amplification, or overexpression) or EGFR exon 20 insertions who have progressed on standard therapies, and treats them with YH42946, an oral tyrosine kinase inhibitor targeting mutant HER2 and EGFR exon 20 insertions.
ClinicalTrials.gov ID: NCT06616766
TrialFetch AI summary: This trial enrolls adults with advanced or metastatic solid tumors linked to COX2-mediated immunosuppression who have exhausted standard therapies, including specific expansion cohorts for sarcoma, pancreatic cancer, NSCLC without driver mutations, microsatellite stable/low colorectal cancer, and head and neck squamous cell carcinoma. Patients receive OKN4395, an oral triple antagonist of EP2, EP4, and DP1 prostanoid receptors, as monotherapy or in combination with pembrolizumab.
ClinicalTrials.gov ID: NCT06789172
TrialFetch AI summary: This trial enrolls adults with locally advanced or metastatic NSCLC harboring EGFR (including classical, atypical, exon 20 insertion, and resistance mutations) and/or HER2 kinase domain mutations who have received standard therapies, testing the investigational oral agent BH-30643, a mutant-selective OMNI-EGFR inhibitor targeting a broad spectrum of EGFR and HER2 mutations. Patients must have measurable disease, good performance status, and no significant comorbidities or prior ILD.
ClinicalTrials.gov ID: NCT06706076
TrialFetch AI summary: Adults with advanced unresectable or metastatic melanoma (non-uveal/mucosal), head and neck squamous cell carcinoma, non-small cell lung cancer, triple negative breast cancer, or classical Hodgkin lymphoma who have progressed on prior PD-1/PD-L1 therapy are eligible to receive CTX-8371, an investigational bispecific antibody targeting PD-1 and PD-L1 designed to overcome checkpoint inhibitor resistance, as monotherapy.
ClinicalTrials.gov ID: NCT06150664
TrialFetch AI summary: This trial enrolls adults with advanced or metastatic Claudin-1 positive squamous solid tumors (including SqNSCLC, HNSCC, ESCC, or CSCC) who are refractory or intolerant to standard therapies. Patients receive ALE.P02, a CLDN1-targeted antibody-drug conjugate that delivers a tubulin inhibitor selectively to CLDN1-positive tumor cells.
ClinicalTrials.gov ID: NCT06747585