Clinical Trials for Cervical Cancer

Restoration of Radioiodine Uptake with Selpercatinib in RET Fusion-Positive Radioiodine-Refractory Thyroid Cancer: a Phase 2 Study Performed in Collaboration with the International Thyroid Oncology Group (ITOG)

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

Started >3 years ago

The trial was activated more than 3 years ago. This is not always bad but can indicate that the trial has less current treatments, or has had trouble getting enough patients to enroll due to other issues.

TrialFetch AI summary: RET fusion–positive, radioiodine-refractory differentiated thyroid cancer (adolescents ≥12 and adults) with metastatic/unresectable disease, limited prior therapy, and no prior RET TKI receive a short selpercatinib lead-in (selective RET kinase inhibitor) to restore radioiodine uptake followed by therapeutic I-131 under rhTSH, with an option for a second selpercatinib/I-131 course if uptake is restored. Key allowances include treated/stable brain metastases; exclusions include QT-prolonging risks and recent I-131.

ClinicalTrials.gov ID: NCT05668962

Administration of T Cells Expressing Chondroitin-Sulfate-Proteoglycan-4 Specific Chimeric Antigen Receptors (CAR) in Subjects With Head and Neck Squamous Cell Carcinoma (HNSCC)

High burden on patient

The trial has a high burden on patients. An example would be a phase 1 trial with extra tumor biopsies and frequent pharmacokinetic blood draws.

TrialFetch AI summary: Adults with previously treated recurrent/metastatic HNSCC (oral cavity, oropharynx, hypopharynx, larynx; KPS >60%) receive lymphodepleting cyclophosphamide/fludarabine followed by a single infusion of autologous iC9.CAR-CSPG4 T cells, an anti-CSPG4 CAR T product with an inducible caspase-9 safety switch for potential rapid ablation. Key exclusions include significant cardiovascular disease, recent stroke/TIA, and severe hypersensitivity to cyclophosphamide or fludarabine.

ClinicalTrials.gov ID: NCT06096038

An Open Label Phase II Trial Evaluating the Efficacy of Cyclophosphamide and Sirolimus for the Treatment of Metastatic, RAI-refractory, Differentiated Thyroid Cancer

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

Started >3 years ago

The trial was activated more than 3 years ago. This is not always bad but can indicate that the trial has less current treatments, or has had trouble getting enough patients to enroll due to other issues.

TrialFetch AI summary: Adults with metastatic, RAI‑refractory differentiated thyroid cancer with RECIST-defined progression (ECOG 0–2) receive oral cyclophosphamide (intermittent low-dose) plus sirolimus daily. Sirolimus targets mTORC1 (PI3K/AKT/mTOR pathway inhibition), aiming for antiproliferative/antiangiogenic synergy with metronomic cyclophosphamide; excludes prior mTOR inhibitor exposure and requires available prior NGS.

ClinicalTrials.gov ID: NCT03099356

Phase I Study of Preconditioning Radiation Therapy With IL-15 Transduced TGFBR2 KO CAR.TROP2-engineered Cord Blood-derived NK Cells in Patients With Advanced Head and Neck Cancer (RADIANCE-NK)

High burden on patient

The trial has a high burden on patients. An example would be a phase 1 trial with extra tumor biopsies and frequent pharmacokinetic blood draws.

TrialFetch AI summary: Adults with locally advanced unresectable or metastatic/oligometastatic (≤5 sites) HPV+ or HPV− head and neck squamous cell carcinoma with measurable TROP2 IHC 2+/3+ disease and ECOG 0–1 receive lymphodepleting fludarabine/cyclophosphamide followed by allogeneic cord blood–derived TROP2-directed CAR-NK cells engineered to express IL-15 (to support NK persistence) and with TGFBR2 knockout (to resist TGF-β–mediated immunosuppression). Patients are treated in cohorts with CAR-NK therapy alone versus with preconditioning radiation/SBRT bridging when feasible (often leaving one measurable lesion unirradiated for response assessment).

ClinicalTrials.gov ID: NCT07101432

Feasibility Trial of Pembrolizumab Plus Ultrasound-Induced Microbubble Cavitation in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

High burden on patient

The trial has a high burden on patients. An example would be a phase 1 trial with extra tumor biopsies and frequent pharmacokinetic blood draws.

TrialFetch AI summary: Enrolls adults with HPV-negative, PD-L1 CPS >1 recurrent/metastatic head and neck squamous cell carcinoma, no prior checkpoint inhibitor therapy, and an ultrasound- and biopsy-accessible measurable lesion. Patients receive pembrolizumab, an anti–PD-1 antibody, with Definity perflutren microbubbles and tumor-directed ultrasound-induced cavitation intended to enhance intratumoral drug delivery and immune response.

ClinicalTrials.gov ID: NCT07501650

An Open-Label, Single-Arm, Phase 2 Study to Evaluate the Efficacy and Safety of Tislelizumab Plus Chemotherapy in a First-Line Setting for Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Adenocarcinoma and Esophageal Squamous Cell Carcinoma in US Racial and Ethnic Minority Patients

High burden on patient

The trial has a high burden on patients. An example would be a phase 1 trial with extra tumor biopsies and frequent pharmacokinetic blood draws.

TrialFetch AI summary: Adults from US racial or ethnic minority populations with previously untreated PD-L1-positive, locally advanced unresectable or metastatic HER2-negative gastric/gastroesophageal adenocarcinoma or esophageal squamous cell carcinoma receive tislelizumab, an anti–PD-1 antibody, plus first-line platinum/fluoropyrimidine chemotherapy (FOLFOX, CAPOX, or cisplatin/5-FU depending on tumor type).

ClinicalTrials.gov ID: NCT07554521

Phase II Basket Trial of Intraperitoneal Paclitaxel Plus Systemic Therapy in Gastrointestinal Malignancies With Peritoneal Carcinomatosis (STOPGAP - B)

High burden on patient

The trial has a high burden on patients. An example would be a phase 1 trial with extra tumor biopsies and frequent pharmacokinetic blood draws.

TrialFetch AI summary: Adults with gastrointestinal adenocarcinoma and positive peritoneal cytology or peritoneal carcinomatosis, including gastric/GEJ, colorectal, appendiceal, and other digestive-tract cancers, receive intraperitoneal paclitaxel every 2 or 3 weeks with systemic chemotherapy. Paclitaxel is a microtubule-stabilizing taxane; the gastric/GEJ regimen includes IV paclitaxel, 5-fluorouracil, and leucovorin.

ClinicalTrials.gov ID: NCT07795749

A Phase I/II Study of Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab in Advanced Solid Tumors (PNeoVCA)

Started >3 years ago

The trial was activated more than 3 years ago. This is not always bad but can indicate that the trial has less current treatments, or has had trouble getting enough patients to enroll due to other issues.

High burden on patient

The trial has a high burden on patients. An example would be a phase 1 trial with extra tumor biopsies and frequent pharmacokinetic blood draws.

TrialFetch AI summary: This trial involves adults with unresectable or metastatic advanced solid tumors who have progressed on prior treatments or are candidates for pembrolizumab, combining pembrolizumab, which targets the PD-1 receptor to enhance immune response, with a personalized neoantigen peptide vaccine designed to stimulate an individualized immune attack against tumor-associated proteins.

ClinicalTrials.gov ID: NCT05269381

A Phase 1, First-in-Human, Open-Label, Multi-Center, Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LB-LR1109 for the Treatment of Advanced or Metastatic Solid Tumors

No known activity

No investigational drug(s) in this trial have shown anticancer activity yet in clinical trials

High burden on patient

The trial has a high burden on patients. An example would be a phase 1 trial with extra tumor biopsies and frequent pharmacokinetic blood draws.

TrialFetch AI summary: Adults with advanced or metastatic NSCLC, head and neck squamous cell carcinoma, renal cell carcinoma, urothelial carcinoma, or melanoma who lack a suitable standard treatment option receive escalating doses of LB-LR1109 monotherapy. This investigational antibody blocks the inhibitory immune receptor LILRB1 to enhance antitumor immune activity.

ClinicalTrials.gov ID: NCT06332755

A Phase 1/2, Open-Label, Multi-Center, First-in-Human Study of the Safety, Tolerability, Pharmacokinetics, and Anti-Tumor Activity of TPX-0005 in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements (TRIDENT-1)

Started >3 years ago

The trial was activated more than 3 years ago. This is not always bad but can indicate that the trial has less current treatments, or has had trouble getting enough patients to enroll due to other issues.

High burden on patient

The trial has a high burden on patients. An example would be a phase 1 trial with extra tumor biopsies and frequent pharmacokinetic blood draws.

TrialFetch AI summary: This trial enrolls adults and adolescents with advanced or metastatic solid tumors (including NSCLC) harboring ALK, ROS1, or NTRK1-3 gene rearrangements to receive repotrectinib, a next-generation oral tyrosine kinase inhibitor designed to overcome resistance mutations in these oncogenic fusions. Eligible patients may have received prior TKIs and may have asymptomatic CNS metastases.

ClinicalTrials.gov ID: NCT03093116