Trial: A Phase III Study of Dato-DXd With or W…

Trial Details

Sponsor: AstraZeneca (industry)

Phase: 3

Start date: Nov. 23, 2023

Planned enrollment: 625

Trial ID: NCT06103864

More trial details at ClinicalTrials.gov

Show Summary from Sponsor

Investigational Drug AI Analysis

Show for: Datopotamab deruxtecan (Dato-DXd, DS-1062)

Overview

Datopotamab deruxtecan (Dato-DXd; DS-1062; marketed as Datroway) is a TROP2-directed antibody–drug conjugate developed for solid tumors. It is no longer solely investigational: in the United States it is approved for selected patients with HR-positive/HER2-negative or triple-negative breast cancer and, under accelerated approval, previously treated EGFR-mutated non-small-cell lung cancer (NSCLC). Studies in other disease settings and treatment combinations remain ongoing. (fda.gov)

Mechanism of action

Dato-DXd comprises a humanized anti-TROP2 IgG1 antibody connected through a cleavable linker to DXd, a potent exatecan-derived topoisomerase-I inhibitor. After binding TROP2 and internalization, lysosomal processing releases DXd, causing DNA damage and apoptosis. Preclinical evidence also supports a bystander effect against neighboring cells and induction of features associated with immunogenic cell death. (pmc.ncbi.nlm.nih.gov)

Efficacy

Previously treated HR-positive/HER2-negative breast cancer: In the randomized phase III TROPION-Breast01 trial (732 patients), Dato-DXd improved progression-free survival versus investigator-selected chemotherapy (hazard ratio 0.63). Objective response rates were 36.4% versus 22.9%, with median response durations of 6.7 and 5.7 months, respectively. Overall-survival data were immature in the primary publication. (ascopubs.org)
Previously untreated advanced triple-negative breast cancer unsuitable for immunotherapy: In phase III TROPION-Breast02 (644 patients), median progression-free survival was 10.8 versus 5.6 months, median overall survival was 23.7 versus 18.7 months, and objective response rates were approximately 63–64% versus 29–30% for Dato-DXd and chemotherapy, respectively. (sciencedirect.com)
Previously treated advanced NSCLC: In phase III TROPION-Lung01, median progression-free survival was 4.4 versus 3.7 months with Dato-DXd and docetaxel, while overall survival did not differ significantly. Benefit was concentrated in the prespecified nonsquamous subgroup; outcomes did not favor Dato-DXd in squamous disease. (pubmed.ncbi.nlm.nih.gov)
Previously treated EGFR-mutated NSCLC: A pooled FDA analysis of 114 patients from TROPION-Lung05 and TROPION-Lung01 found an objective response rate of 45% and median response duration of 6.5 months, supporting accelerated approval. (fda.gov)

Safety

The characteristic toxicities include stomatitis/oral mucositis, nausea, ocular-surface reactions, alopecia and fatigue. Interstitial lung disease/pneumonitis is an important, potentially fatal risk requiring monitoring and treatment interruption when suspected. (pubmed.ncbi.nlm.nih.gov)

In TROPION-Breast01, grade 3 or higher treatment-related adverse events occurred in 20.8% with Dato-DXd versus 44.7% with chemotherapy; treatment-related oral mucositis/stomatitis occurred in 57.2%, ocular-surface events in 43.9%, and adjudicated drug-related pneumonitis in 3.9%, including one fatal event. In TROPION-Lung01, grade 3 or higher treatment-related events occurred in 25.6% versus 42.1% with docetaxel, while drug-related pneumonitis was more frequent with Dato-DXd (8.8% versus 4.1%). (ascopubs.org)

TrialFetch AI Analysis

Goal: Determine whether datopotamab deruxtecan (Dato-DXd) plus durvalumab improves blinded independent central review–assessed progression-free survival versus investigator’s choice chemotherapy plus pembrolizumab as first-line treatment for PD-L1–positive advanced triple-negative breast cancer (TNBC).

Patients: Patients with inoperable locally recurrent or metastatic TNBC, centrally confirmed PD-L1 combined positive score ≥10, measurable disease, and ECOG performance status 0–1. They must have received no systemic therapy for advanced disease; recurrence after curative-intent treatment is eligible if at least 6 months have elapsed. Tumor tissue is required for screening.

Design: International, multicenter, open-label, randomized, three-arm trial. Randomization is stratified by geographic region, disease-free interval, and prior PD-1/PD-L1 treatment for early-stage TNBC.

Treatments: Patients receive Dato-DXd plus durvalumab, Dato-DXd alone, or investigator’s choice of paclitaxel, nab-paclitaxel, or gemcitabine plus carboplatin, each combined with pembrolizumab. Dato-DXd is a TROP2-directed antibody–drug conjugate that delivers a topoisomerase I inhibitor payload after cellular uptake. In a separate phase III trial of previously untreated advanced TNBC unsuitable for immunotherapy, Dato-DXd improved progression-free and overall survival versus chemotherapy; those findings do not establish its benefit in this PD-L1–positive population or with durvalumab. Durvalumab and pembrolizumab are immune checkpoint inhibitors; the chemotherapy–pembrolizumab arm is the active comparator.

Outcomes: The primary endpoint is progression-free survival by RECIST 1.1 and blinded independent central review for Dato-DXd plus durvalumab versus chemotherapy plus pembrolizumab. Secondary measures include overall survival, response rate and duration, investigator-assessed progression-free survival, 24-week clinical benefit, patient-reported symptoms, pain, physical function and quality of life, subsequent-therapy outcomes, safety, and Dato-DXd pharmacokinetics and immunogenicity.

Burden on patient: Estimated burden is moderate. Treatment visits, serial imaging and laboratory assessments, safety monitoring, and patient-reported questionnaires add time and travel; pharmacokinetic and antidrug-antibody testing require additional blood sampling. Screening requires tumor tissue, although an eligible archival sample may avoid a new biopsy. Visit and scan frequencies are not specified, so the incremental burden over usual first-line treatment cannot be quantified.

Last updated: Sep 2026

Eligibility

Caution: ClinicalTrials.gov appears to have newer eligibility criteria than the version saved here. Review the current criteria in ClinicalTrials.gov.

Show Criteria

Key Inclusion Criteria

* Histologically or cytologically documented locally recurrent inoperable, which cannot be treated with curative intent, or metastatic TNBC, as defined by the ASCO-CAP guidelines.

* ECOG PS 0 or 1.

* Participants are expected to provide an FFPE tumour sample collected from a locally recurrent inoperable or metastatic tumour. If no such sample is available, an archival FFPE tumour sample can be submitted; it must have been collected ≤ 3 years prior to the participant signing informed consent (screening start).

* PD-L1 positive TNBC based on results from an appropriately validated investigational PD-L1 (22C3) assay (CPS ≥ 10) from a sponsor designated central laboratory.

* No prior chemotherapy or other systemic anti-cancer therapy for metastatic or locally recurrent inoperable breast cancer.

- Patients with recurrent disease will be eligible if they have completed treatment for Stage I-III breast cancer, if indicated, and ≥6 months have elapsed between completion of treatment with curative intent and the first documented recurrence.

* Eligible for one of the chemotherapy options listed as ICC (paclitaxel, nab-paclitaxel, or gemcitabine + carboplatin).

* Measurable disease as per RECIST 1.1.

* Adequate bone marrow reserve and organ function.

* Male and female participants of childbearing potential must agree to use protocol-specified method(s) of contraception.

Key Exclusion Criteria

* As judged by investigator, any evidence of diseases (such as severe or uncontrolled medical conditions including systemic diseases, uncontrolled hypertension, serious gastrointestinal conditions associated with diarrhoea, chronic diverticulitis or previous complicated diverticulitis, history of allogeneic organ transplant, and active bleeding diseases, ongoing and active infection, significant cardiac conditions, substance abuse, psychiatric illness/social situation or psychological conditions) which, in the investigator's opinion, makes it undesirable for the participant to participate in the study or that would jeopardize compliance with the protocol.

* History of another primary malignancy except for malignancy treated with curative intent with no known active disease within 3 years before Cycle 1 Day 1 and of low potential risk for recurrence.

* Participants with a history of previously treated neoplastic spinal cord compression or treated, clinically inactive brain metastases that are no longer symptomatic, who require no treatment with corticosteroids or anticonvulsants, may be included in the study if they have recovered from acute toxic effects of radiotherapy.

- Participants with treated clinically inactive brain metastases that are no longer symptomatic, who require no treatment with corticosteroids or anticonvulsants, may be included in the study if they have recovered from acute toxic effects of radiotherapy.

* Uncontrolled infection requiring IV antibiotics, antivirals or antifungals.

* Active or uncontrolled hepatitis B or C virus infection.

* Known HIV infection that is not well controlled.

* Uncontrolled or significant cardiac disease.

* History of non-infectious ILD/pneumonitis (including radiation pneumonitis) that required steroids, current ILD/pneumonitis, or suspected ILD/pneumonitis that cannot be ruled out by imaging at screening.

* Severe pulmonary function compromise.

* Clinically significant corneal disease.

* Active or prior documented autoimmune or inflammatory disorders.

* Prior exposure to any treatment including ADC containing a chemotherapeutic agent targeting topoisomerase I and TROP2-targeted therapy.

* Any concurrent anti-cancer treatment.

* Participants with a known severe hypersensitivity to PD-1/PD-L1 inhibitors or Dato-DXd.

* Currently pregnant (confirmed with positive pregnancy test), breastfeeding or planning to become pregnant.

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Ciudad Autónoma Buenos Aires, C1430EFA, Argentina

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Goiânia, 74000-000, Brazil

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Greenfield Park, Quebec, J4V 2H1, Canada

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Zhanjiang, 524003, China

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Xuzhou, 221009, China

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Xintai, 54031, China

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Xiamen, 361003, China

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Xi'an, 710061, China

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Wuhan, 430079, China

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Wuhan, 430022, China

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Nanjing, 210009, China

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Nanjing, 2100008, China

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Nanchang, 330009, China

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Jinan, 250021, China

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Hefei, 230031, China

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Harbin, 150081, China

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Hangzhou, 310022, China

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Hangzhou, 310016, China

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Hangzhou, 310009, China

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Guangzhou, 510700, China

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Guangzhou, 510120, China

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Guangzhou, 510060, China

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Fuzhou, 350014, China

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Chengdu, 610041, China

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Chengdu, 610000, China

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Changsha, 410013, China

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Changsha, 410008, China

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Changchun, 130021, China

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Bengbu, 233004, China

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Beijing, 100142, China

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Beijing, 100044, China

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Anyang, 455000, China

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Nanning, 530021, China

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Shandong, China

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Shanghai, 200025, China

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Shenyang, 110004, China

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Tianjin, 300000, China

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Wenzhou, 325000, China

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Zhengzhou, 450052, China

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Zhengzhou, 450008, China

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Montpellier, 34298, France

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Villejuif, 94800, France

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Vandœuvre-lès-Nancy, 54511, France

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Toulouse, 31059, France

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Saint-Herblain, 44805, France

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Paris, 75020, France

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Lyon, 69373, France

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Lille, 59000, France

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Shatin, 00000, Hong Kong

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Hong Kong, 999077, Hong Kong

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Hong Kong, Hong Kong

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Marg Jaipur, 302004, India

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Mohali, 160055, India

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Mysuru, 570017, India

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Nagpur, 440001, India

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New Delhi, 110075, India

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Nashik, 422009, India

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New Delhi, 11029, India

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Puducherry, 605006, India

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Surat, 395002, India

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Vadodara, 391760, India

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Chennai, 600031, India

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Milan, 20132, Italy

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Naples, 80131, Italy

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Padova, 35128, Italy

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Reggio Emilia, 42123, Italy

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Roma, 00168, Italy

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Rozzano, 20089, Italy

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Bergamo, 24127, Italy

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Empoli, 50053, Italy

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Milan, 20141, Italy

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Ota-shi, 373-8550, Japan

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Yokohama, 241-8515, Japan

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Tsukuba, 305-8577, Japan

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Tsu, 514-8507, Japan

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Shinjuku-ku, 162-8655, Japan

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Shinjuku-ku, 160-0023, Japan

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Shinagawa-ku, 142-8666, Japan

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Sendai, 980-8574, Japan

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Akashi-shi, 673-8558, Japan

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Bunkyō City, 113-8431, Japan

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Bunkyō City, 113-8677, Japan

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Chiba, 260-8717, Japan

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Chūōku, 104-0045, Japan

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Fukuoka, 811-1395, Japan

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Fukushima, 960-1295, Japan

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Gifu, 501-1194, Japan

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Hidaka-shi, 350-1298, Japan

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Hiroshima, 730-8518, Japan

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Hiroshima, 734-8551, Japan

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Isehara-shi, 259-1193, Japan

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Kamogawa-shi, 296-8602, Japan

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Kashiwa, 277-8577, Japan

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Kitaadachi-gun, 362-0806, Japan

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Kōtoku, 135-8550, Japan

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Kumamoto, 860-8556, Japan

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Kurume-shi, 830-0011, Japan

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Matsuyama, 791-0280, Japan

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Nagoya, 466-8560, Japan

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Nagoya, 467-8602, Japan

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Niigata, 951-8566, Japan

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Nishinomiya-shi, 663-8501, Japan

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Okayama, 700-8558, Japan

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Osaka, 541-8567, Japan

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Osakasayama-shi, 589-8511, Japan

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Sapporo, 003-0804, Japan

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Guadalajara, 44638, Mexico

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Mexico City, 0 3100, Mexico

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México, 04700, Mexico

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México, 6760, Mexico

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Tuxtla Gutiérrez, 29090, Mexico

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CD Mexico, 04980, Mexico

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City of Muntinlupa, 1780, Philippines

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Bacolod, 6100, Philippines

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Manila, 1000, Philippines

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Cebu City, 6000, Philippines

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San Juan City, 1502, Philippines

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Quezon City, 1112, Philippines

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Warsaw, 02-781, Poland

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Lodz, 90-302, Poland

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Singapore, 169610, Singapore

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Singapore, 308433, Singapore

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Singapore, 217562, Singapore

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Paarl, 7646, South Africa

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Cape Town, 7570, South Africa

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Johannesburg, 2013, South Africa

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Johannesburg, 2193, South Africa

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Johannesburg, 2196, South Africa

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Pretoria, 0081, South Africa

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Seoul, 06273, South Korea

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Seoul, 05505, South Korea

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Seoul, 03722, South Korea

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Seoul, 03080, South Korea

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Seoul, 02841, South Korea

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Seongnam-si, 13620, South Korea

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Goyang-si, 10408, South Korea

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Daegu, 41404, South Korea

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Seoul, 06591, South Korea

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Seoul, 06351, South Korea

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Pamplona, 31008, Spain

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Madrid, 28007, Spain

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Hospitalet deLlobregat, 08907, Spain

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Barcelona, 8035, Spain

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Kaohsiung City, 80756, Taiwan

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Hsinchu, 300, Taiwan

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Taichung, 40447, Taiwan

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Tainan, 704, Taiwan

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Taipei, 100, Taiwan

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Taipei, 10449, Taiwan

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Taipei, 11259, Taiwan

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Taipei, 112, Taiwan

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Taoyuan District, 333, Taiwan

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Bangkok, 10330, Thailand

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Bangkok, 10210, Thailand

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Songkhla, 90110, Thailand

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Khon Kaen, 40002, Thailand

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Dusit, 10300, Thailand

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Chiang Mai, 50200, Thailand

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Bangkok, 10400, Thailand

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Besevler Ankara, Turkey (Türkiye)

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Ankara, 06520, Turkey (Türkiye)

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Samsun, 55200, Turkey (Türkiye)

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Küçükçekmece, 34295, Turkey (Türkiye)

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Istanbul, 34010, Turkey (Türkiye)

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Ankara, 6200, Turkey (Türkiye)

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London, EC1A 7BE, United Kingdom

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Sutton, SM2 5PT, United Kingdom

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Leicester, Le5 4PW, United Kingdom

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Chelsea, SW3 6JJ, United Kingdom

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Cardiff, CF14 2TL, United Kingdom

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Taunton, TA1 5DA, United Kingdom

No email / No phone

Status: Recruiting

Research Site

Daphne, Alabama, 36526, United States

No email / No phone

Status: Recruiting

Research Site

Springdale, Arkansas, 72762, United States

No email / No phone

Status: Recruiting

Research Site

Glendale, California, 91204, United States

No email / No phone

Status: Recruiting

Research Site

Sacramento, California, 95817, United States

No email / No phone

Status: Recruiting

Research Site

Aurora, Colorado, 80012, United States

No email / No phone

Status: Recruiting

Research Site

New Haven, Connecticut, 06510, United States

No email / No phone

Status: Recruiting

Research Site

Plantation, Florida, 33324, United States

No email / No phone

Status: Recruiting

Research Site

Miami, Florida, 33176, United States

No email / No phone

Status: Recruiting

Research Site

Chicago, Illinois, 60637, United States

No email / No phone

Status: Recruiting

Research Site

Des Moines, Iowa, 50309, United States

No email / No phone

Status: Recruiting

Research Site

Baton Rouge, Louisiana, 70809, United States

No email / No phone

Status: Recruiting

Research Site

Columbia, Maryland, 21044, United States

No email / No phone

Status: Recruiting

Research Site

Detroit, Michigan, 48201, United States

No email / No phone

Status: Recruiting

Research Site

Saint Paul, Minnesota, 55109, United States

No email / No phone

Status: Recruiting

Research Site

St Louis, Missouri, 63129, United States

No email / No phone

Status: Recruiting

Research Site

Albuquerque, New Mexico, 87109, United States

No email / No phone

Status: Recruiting

Research Site

Stony Brook, New York, 11794-7263, United States

No email / No phone

Status: Recruiting

Research Site

New York, New York, 10065, United States

No email / No phone

Status: Recruiting

Research Site

Cleveland, Ohio, 44195, United States

No email / No phone

Status: Recruiting

Research Site

Cincinnati, Ohio, 45245, United States

No email / No phone

Status: Recruiting

Research Site

Cincinnati, Ohio, 45219, United States

No email / No phone

Status: Recruiting

Research Site

Providence, Rhode Island, 02903, United States

No email / No phone

Status: Recruiting

Research Site

Chattanooga, Tennessee, 37404, United States

No email / No phone

Status: Recruiting

Research Site

Nashville, Tennessee, 37203, United States

No email / No phone

Status: Recruiting

Research Site

Dallas, Texas, 75246, United States

No email / No phone

Status: Recruiting

Research Site

El Paso, Texas, 79902, United States

No email / No phone

Status: Recruiting

Research Site

Sugar Land, Texas, 77479, United States

No email / No phone

Status: Recruiting

Research Site

Midlothian, Virginia, 23114, United States

No email / No phone

Status: Recruiting

Research Site

Roanoke, Virginia, 24014, United States

No email / No phone

Status: Recruiting

Research Site

Norfolk, Virginia, 23502, United States

No email / No phone

Status: Recruiting

Research Site

Charlottesville, Virginia, 22903, United States

No email / No phone

Status: Recruiting

Research Site

Fairfax, Virginia, 22031, United States

No email / No phone

Status: Recruiting

Research Site

Tacoma, Washington, 98405, United States

No email / No phone

Status: Recruiting

Research Site

Ho Chi Minh City, 700000, Vietnam

No email / No phone

Status: Recruiting

Research Site

Hanoi, 100000, Vietnam

No email / No phone

Status: Recruiting

Research Site

Da Nang, 550000, Vietnam

No email / No phone

Status: Recruiting

Research Site

Hồ Chí Minh, 700000, Vietnam

No email / No phone

Status: Recruiting

Research Site

Huế, 530000, Vietnam

No email / No phone

Status: Recruiting

Research Site

Viet Tri, 35000, Vietnam

No email / No phone

Status: Recruiting

Research Site

Vinh, 460000, Vietnam

No email / No phone

Status: Recruiting

Research Site

Pretoria, 0081, South Africa

No email / No phone

Status: Active, not recruiting

Research Site

Meizhou, 514031, China

No email / No phone

Status: Not yet recruiting

Research Site

Hong Kong, 999077, Hong Kong

No email / No phone

Status: Not yet recruiting

Research Site

Jaipur, 302004, India

No email / No phone

Status: Not yet recruiting

Research Site

Krakow, 31-501, Poland

No email / No phone

Status: Not yet recruiting

Research Site

Gdansk, 80-952, Poland

No email / No phone

Status: Not yet recruiting

Research Site

Bangkok, 10700, Thailand

No email / No phone

Status: Not yet recruiting

Research Site

Darlinghurst, 2010, Australia

No email / No phone

Status: Completed

Research Site

Heidelberg, 3084, Australia

No email / No phone

Status: Completed

Research Site

Shanghai, 200080, China

No email / No phone

Status: Completed

Research Site

Busan, 49241, South Korea

No email / No phone

Status: Completed

Research Site

CABA, C1425, Argentina

No email / No phone

Status: Withdrawn

Research Site

San Nicolás de los Arroyos, B2900, Argentina

No email / No phone

Status: Withdrawn

Research Site

Waratah, 2298, Australia

No email / No phone

Status: Withdrawn

Research Site

Chongqing, 400030, China

No email / No phone

Status: Withdrawn

Research Site

Heilbronn, 74078, Germany

No email / No phone

Status: Withdrawn

Research Site

Leipzig, 04103, Germany

No email / No phone

Status: Withdrawn

Research Site

Düsseldorf, 40479, Germany

No email / No phone

Status: Withdrawn

Research Site

Essen, 45136, Germany

No email / No phone

Status: Withdrawn

Research Site

Georgsmarienhütte, 49124, Germany

No email / No phone

Status: Withdrawn

Research Site

Hamburg, 20357, Germany

No email / No phone

Status: Withdrawn

Research Site

Hanover, 30625, Germany

No email / No phone

Status: Withdrawn

Research Site

Heidelberg, 69120, Germany

No email / No phone

Status: Withdrawn

Research Site

Visakhapatnam, 530053, India

No email / No phone

Status: Withdrawn

Research Site

Calicut, 673601, India

No email / No phone

Status: Withdrawn

Research Site

Kochi, 682027, India

No email / No phone

Status: Withdrawn

Research Site

Kolkata, 700160, India

No email / No phone

Status: Withdrawn

Research Site

Modena, 41124, Italy

No email / No phone

Status: Withdrawn

Research Site

Guadalajara, 44670, Mexico

No email / No phone

Status: Withdrawn

Research Site

Legnica, 59-220, Poland

No email / No phone

Status: Withdrawn

Research Site

Konin, 62-500, Poland

No email / No phone

Status: Withdrawn

Research Site

Gdynia, 81-519, Poland

No email / No phone

Status: Withdrawn

Research Site

Bydgoszcz, 85-796, Poland

No email / No phone

Status: Withdrawn

Research Site

Bialystok, 15-027, Poland

No email / No phone

Status: Withdrawn

Research Site

Krakow, 31-115, Poland

No email / No phone

Status: Withdrawn

Research Site

Wroclaw, 53-413, Poland

No email / No phone

Status: Withdrawn

Research Site

Przemyśl, 37-700, Poland

No email / No phone

Status: Withdrawn

Research Site

Lublin, 20-090, Poland

No email / No phone

Status: Withdrawn

Research Site

Singapore, 119228, Singapore

No email / No phone

Status: Withdrawn

Research Site

Madrid, 28034, Spain

No email / No phone

Status: Withdrawn

Research Site

Barcelona, 08028, Spain

No email / No phone

Status: Withdrawn

Research Site

Izmir, 35575, Turkey (Türkiye)

No email / No phone

Status: Withdrawn

Research Site

London, SW17 0QT, United Kingdom

No email / No phone

Status: Withdrawn

Research Site

Santa Rosa, California, 95403, United States

No email / No phone

Status: Withdrawn

Research Site

Duarte, California, 91010, United States

No email / No phone

Status: Withdrawn

Research Site

Jacksonville, Florida, 32256, United States

No email / No phone

Status: Withdrawn

Research Site

Palm Bay, Florida, 32909, United States

No email / No phone

Status: Withdrawn

Research Site

Honolulu, Hawaii, 96819, United States

No email / No phone

Status: Withdrawn

Research Site

Elmhurst, Illinois, 60126, United States

No email / No phone

Status: Withdrawn

Research Site

Decatur, Illinois, 62526, United States

No email / No phone

Status: Withdrawn

Research Site

Naperville, Illinois, 60540, United States

No email / No phone

Status: Withdrawn

Research Site

New Albany, Indiana, 47150, United States

No email / No phone

Status: Withdrawn

Research Site

Louisville, Kentucky, 40207, United States

No email / No phone

Status: Withdrawn

Research Site

Lexington, Kentucky, 40503, United States

No email / No phone

Status: Withdrawn

Research Site

Louisville, Kentucky, 40202, United States

No email / No phone

Status: Withdrawn

Research Site

Baton Rouge, Louisiana, 70808, United States

No email / No phone

Status: Withdrawn

Research Site

Baltimore, Maryland, 21215, United States

No email / No phone

Status: Withdrawn

Research Site

Boston, Massachusetts, 02111, United States

No email / No phone

Status: Withdrawn

Research Site

Worcester, Massachusetts, 01655, United States

No email / No phone

Status: Withdrawn

Research Site

Grand Rapids, Michigan, 49503, United States

No email / No phone

Status: Withdrawn

Research Site

Hattiesburg, Mississippi, 39401, United States

No email / No phone

Status: Withdrawn

Research Site

Albany, New York, 12206, United States

No email / No phone

Status: Withdrawn

Research Site

York, Pennsylvania, 17403, United States

No email / No phone

Status: Withdrawn

Research Site

Fort Worth, Texas, 76104, United States

No email / No phone

Status: Withdrawn

Research Site

Dallas, Texas, 75230, United States

No email / No phone

Status: Withdrawn

Research Site

Dallas, Texas, 75246, United States

No email / No phone

Status: Withdrawn

Research Site

Flower Mound, Texas, 75028, United States

No email / No phone

Status: Withdrawn

Research Site

McKinney, Texas, 75071, United States

No email / No phone

Status: Withdrawn

Research Site

Houston, Texas, 77054, United States

No email / No phone

Status: Withdrawn

Research Site

Houston, Texas, 77090, United States

No email / No phone

Status: Withdrawn

Research Site

Houston, Texas, 77098, United States

No email / No phone

Status: Withdrawn

Research Site

Kingwood, Texas, 77339, United States

No email / No phone

Status: Withdrawn

Research Site

Madison, Wisconsin, 53792, United States

No email / No phone

Status: Withdrawn

Research Site

Surrey, GU2 7XX, United Kingdom

No email / No phone

Status: SUSPENDED

Research Site

Oxford, OX3 7LE, United Kingdom

No email / No phone

Status: SUSPENDED

Research Site

Liverpool, L7 8YA, United Kingdom

No email / No phone

Status: SUSPENDED

Research Site

Atlanta, Georgia, 30318, United States

No email / No phone

Status: SUSPENDED

Trial Details

Show Summary from Sponsor

More details:

Investigational Drug AI Analysis

Show for: Datopotamab deruxtecan (Dato-DXd, DS-1062)

Overview

Mechanism of action

Efficacy

Safety

Further reading

TrialFetch AI Analysis

Eligibility

Show Criteria

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